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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-356264 |
NBP1-02973 |
c Abl [phospho Tyr412] Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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c Abl [phospho Tyr412] Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC-P | | Clonality: | Polyclonal | | | Gene: | ABL1 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | Amino acids surrounding Tyrosine 412 | Details: | Modification: | phospho Tyr412 | | Immunogen: | Amino acids surrounding Tyrosine 412 | Gene Symbol: ABL1 | Entrez: | 25 (Human) | | | 11350 (Mouse) | | Swiss Prot: | P00519 (Human) | | Related Genes: | BCR, MTTP, ITGB2, SRC, ITGAL, TP53, ITGAM, MYC, ETV6, CD34, IL3, AKT1, CNTNAP1, KIT, PIK3CG, RUNX1, JAK2, LTBR, CDKN2A, EGFR, BCL2, ITGAX, MLL, BCL2L1, MAPK1, STAT5A, STAT5B, KITLG, PDGFRB, IL2, CDKN1A, PTK2B, EGF, ABI1, GRB2, NOL3, CRK, CR3, JUN, FOS | Background: ABL1, an Abl type protein kinase, is associated with cell differentiation, cell division, cell adhesion and stress response. Kinase activity of nuclear ABL1 is mediated by retinoblastoma protein. Additionally, ABL1 has been shown to bind nuclear DNA, and this binding activity is regulated by CDC2-mediated phosphorylation. ABL1 (-/-) mice are osteoporotic and display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation of B cells in bone marrow. At least two mRNA isoforms have been reported, 6- or 7-kb, with alternatively spliced first exons joined to the common exons 2-11. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation. Further, a very long intron in the ABL1 gene is a target for translocations. Translocations of ABL1 to the breakpoint cluster region (BCR) on chromosome 22 lead to chronic myeloid leukemia and acute lymphocytic leukemia. Species: | Reactivity: | This antibody is reactive to Human, Mouse. | Applications: | Uses: | This antibody is useful for the following applications and at the following dilutions: Immunohistochemistry-Paraffin 20 ug/ml | | Dilutions: | Immunohistochemistry-Paraffin 20 ug/ml, | Packaging: | Buffer: | PBS | | Storage: | Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.05% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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