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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351220 |
NBP1-22814 |
Actin Alpha Skeletal/Cardiac Antibody (5C5)//Am, Bovine,/Mouse |
1/EA |
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문의 |
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Subject
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Actin Alpha Skeletal/Cardiac Antibody (5C5) |
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Description
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/ Am, Bovine,/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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IHC-P, IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Re, Sh, Fi, Am, GP, Rb, Rt, Hu, Bv | | Applications: | IHC-P, IHC | | Clonality: | Monoclonal | | | Gene: | ACTA1 | | Purity: | IgG purified | | Host: | Mouse | | | Specificity: | Monoclonal anti-alpha-sarcomeric Actin has been used as a marker for rhabdomyosarcoma. This antibody is specific to alpha-skeletal and alpha-cardiac muscle actins. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | 5C5 | | Isotype: | IgM | | Immunogen: | BALB/C mice were injected with purified rabbit striated muscle actin. | Gene Symbol: ACTA1 | Entrez: | 58 (Human) | | | 29437 (Rat) | | | 70 (ACTC1) | | Related Genes: | ALB, EPR, VIM, YWHAZ, INS, CYCS, CAT, DES, NEB, ESR1, MYH14, BBS9, CD34, ACHE, TF, POMC, TPM3, MB, EXOSC10, ATP6V0A1, RFC2, RFC1, RFC4, DSC3, PLA2G4A, APOA1, AKR1A1, GLYAT, PLG, A4GALT, ELN, MPO, EPO, RPLP2, C2, C4A, CEL, HNRNPC, VDAC1, PMP2 | Background: Actins are highly conserved proteins ubiquitously expressed in all eukaryotic cells. They comprise, along with microtubules, a major component of the cytoskeleton. Actin has been found to be expressed in at least six isomeric forms. It is expressed in heart and skeletal striated muscle tissue, and in certain smooth muscle tissues, regulating contractile potentials for these cells. It is also expressed in the cytoplasm of non-muscle cells, functioning to control cell structure and motility (1). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin), whose formation requires the Arp2/3 complex (2). It has been reported that actin is hyperphosphorylated in primary breast tumors (3). It has also been shown that actin dysfunction leads to certain types of heart failure (4). Species: | Reactivity: | Human, Sheep, Bovine, Rabbit, Guinea pig, Rat, Frog, Snake, and Carp. It does not react with smooth muscle tissue. | Applications: | Uses: | This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded and acetone fixed cryostat tissue sections. No further titration is required. | | Dilutions: | immunohistochemistry , Immunohistochemistry-Paraffin | Packaging: | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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