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| Cat. No |
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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351244 |
H00000090-M07 |
Activin A Receptor Type I Antibody (2D5)//Human/Mouse |
1/EA |
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문의 |
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Subject
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Activin A Receptor Type I Antibody (2D5) |
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Description
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/ Human/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Protein Type: | Partial Protein | | Species: | Hu | | Applications: | WB, ELISA | | Clonality: | Monoclonal | | | Gene: | ACVR1 | | Purity: | protein A purified | | Host: | Mouse | | | Specificity: | Reacts with activin A receptor, type I. | Details: | Clone: | 2D5 | | Isotype: | IgG1 Kappa | | Immunogen: | ACVR1 (AAH33867, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | | Epitope: | MEDEKPKVNPKLYMCVCEGLSCGNED HCEGQQCFSSLSINDGFHVYQKGCFQ VYEQGKMTCKTPPSPGQAVECCQGDW CNRNITAQLPTKGKSFPGTQNF | Gene Symbol: ACVR1 | Entrez: | 90 (Human) | | Swiss Prot: | AAH33867 (Human) | | Related Genes: | BMP4, ACVR1B, BMP7, BMPR1A, GARS, SMAD1, BMP2, ACVR2A, BMPR1B, ACVR2B, ACVRL1, SMAD2, TGFBR1, TGFB1, BMPR2, SLPI, FGFR1OP, TDGF1, NODAL, FGFR1, ALK, SMAD5, SMAD9, NOG, FST, ACVR1C, TGFBR3, BRD2, SMAD4, BMP-2, BMPRII, VEGFA, BMP6, DAND5, SMAD3, ZMYM2, EGF, MAPK1, SPP1, AMHR2 | Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq] Species: Applications: | Uses: | This antibody is reactive against recombinant protein in western blot and ELISA. | | Dilutions: | ELISA,Western Blot, | Notes: Genbank Accession: BC033867 This product is produced by and distributed for Abnova, a company based in Taiwan. Packaging: | Buffer: | 1x PBS, pH 7.2 | | Storage: | Store at -20C. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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