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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351448 |
NBP1-02433 |
ADAM10 Antibody//Bovine, Human/Rabbit |
1/EA |
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문의 |
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Subject
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ADAM10 Antibody |
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Description
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/ Bovine, Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, IF, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu, Bv | | Applications: | IHC-P, IF, ELISA, WB | | Clonality: | Polyclonal | | | Gene: | ADAM10 | | Purity: | Delipidation and Defibrination | | Host: | Rabbit | | | Specificity: | A region near the carboxy terminus of human ADAM10 protein. | Details: | Immunogen: | Synthetic peptide corresponding to A region near the carboxy terminus of human ADAM10 protein | Gene Symbol: ADAM10 | Entrez: | 102 (Human) | | | 11487 (Mouse) | | | 29650 (Rat) | | Swiss Prot: | O14672 (Human) | | Related Genes: | ADAM17, BACE1, NOTCH, ADAM9, EGFR, APP, TNF, PRNP, ADAM15, EGF, ADAM8, CXCL16, ADAM12, PSEN1, HBEGF, L1CAM, CD44, MAPK1, ERBB2, CTNNB1, CDH1, TIMP-1, PKC, BTC, FAM49B, CX3CL1, ABCB6, TIMP1, FURIN, PRDX2, C4BPA, EPHB2, AREG, MMP14, SRC, NOTCH1, GPR151, MRGPRX1, LGR6, OXER1 | Background: Proinflammatory cytokine tumor necrosis factor-alpha (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4). Species: | Reactivity: | This antibody is reactive to Bovine, Human, Mouse, Rat. | Applications: | Uses: | This antibody is useful for the following applications and at the following dilutions: Western Blot 1:500-1:2000, ELISA 1:5000-1:20000, immunofluorescence 1:250-1:1000, Immunohistochemistry-Paraffin 25 ug/ml | | Dilutions: | Western Blot 1:500-1:2000, ELISA 1:5000-1:20000, immunofluorescence 1:250-1:1000, Immunohistochemistry-Paraffin 25 ug/ml, | | Concentrations: | 1.0 mg/ml | Packaging: | Buffer: | PBS | | Storage: | Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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