| Synonyms | Neurogenin-3, ATOH5, NGN3, NEUROG3 |
| Swiss Prot Num | Q5VVI0 |
| Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Neurogenin3. |
| Product Type | Antibodies |
| Storage | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Heremans, Y., et al., J. Cell Biol. 159(2):303-312 (2002). 2. Sommer, L., et al., Mol. Cell. Neurosci. 8(4):221-241 (1996). |
|
| Format | State: Liquid Ig fraction |
| ? | Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS |
| ? | Buffer System: PBS with 0.09% (W/V) sodium azide |
|
| Specificity | This antibody detects Neurogenin3 at N-term. |
| Add. information | Molecular weight: 22968 Da |
| Application | ELISA 1:1,000. Western blot 1:100 - 1:500. |
| Background | Neurogenin-3 belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Neurogenin-3 also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of congenital malabsorptive diarrhea 4 (DIAR4). DIAR4 is an autosomal recessive disorder characterized by generalized malabsorption and a paucity of enteroendocrine cells. |
| Concentration | 0.25 mg/ml |
