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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351600 |
NBP1-19628 |
Adenylate Cyclase 1 Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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Adenylate Cyclase 1 Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC, WB | | Clonality: | Polyclonal | | | Gene: | ADCY1 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | A Cyclase I (D252) detects endogenous levels of A Cyclase I protein. | Details: Gene Symbol: ADCY1 | Entrez: | 107 (Human) | | | 432530 (Mouse) | | Related Genes: | POMC, ADCY7, GCG, PTH, ADCY8, INS, ADCY2, VIP, BCHE, CELA3B, ENOPH1, AVP, ADCY3, PKA, PRL, SCT, ADCY5, PDE3B, PLOD1, CAT, ADCY4, ALDH7A1, GLYAT, CREB1, SST, MAPK1, ALB, BRD2, CA1, ADCY6, PKC, AGT, IL6, EPHB2, IL2, TG, BBS9, ACACA, GNL3, ADCY9 | Background: Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Galpha s) for GTP, the dissociation of GTP-Galpha s from Gbetagamma and Galpha s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. AC I is expressed in myenteric ganglia as two bands of 160 kDa and 185 kDa by SDS-PAGE. Ca2+ stimulation of AC I and AC III is mediated by calmodulin. Protein associated with Myc (PAM) is a very potent inhibitor of AC I. A decrease in endogenous PAM levels in HeLa cells modulate both basal and agonist stimulated cAMP accumulation. Species: Applications: | Uses: | This antibody is useful for Western Blot and Immunohistochemistry. Western blot analysis of A Cyclase I (D252) antibody in extracts from COLO205 cells. Immunohistochemistry analyzes of A Cyclase I (D252) in paraffin-embedded human brain tissue. | | Dilutions: | Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200, | | Concentrations: | 1.0 mg/ml | Packaging: | Buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 15mM Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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