|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-44-53236 |
18-0225 |
Anti-ALPHA CATENIN Monoclonal Antibody, Unconjugated, Clone alpha-CAT-7A4/1 mL/Human, mouse, rat, chicken, and Xenopus. Alpha-catenin has been detected in Western blot analysis of HeLa cells, A431 cells, WI-38 human fibroblasts, Xenopus cytosol, and NIH 3T3 cell lysates./Request Info |
1/EA |
|
|
|
|
문의 |
|
|
|
|
|
|
|
Subject
|
Anti-ALPHA CATENIN Monoclonal Antibody, Unconjugated, Clone alpha-CAT-7A4 |
|
Description
|
1 mL / Human, mouse, rat, chicken, and Xenopus. Alpha-catenin has been detected in Western blot analysis of HeLa cells, A431 cells, WI-38 human fibroblasts, Xenopus cytosol, and NIH 3T3 cell lysates./Request Info |
|
Clonality
|
Mono |
|
Company
|
Invitrogen |
|
Application
|
Immunohistochemistry with formalin-fixed, paraffin-embedded (FFPE) tissue sections, frozen tissue sections, or cell smears. |
|
Conjugation
|
Unconjugated |
|
Immunogen
|
ALPHA CATENIN |
|
Contents
|
Alpha-Catenin is a 102 kDa protein that is related to the cytoskeletal protein vinculin(1). Vinculin associates with both cell-cell and cell-extracellular matrix adherens-type junctions, and has been shown to interact with both alpha-actinin and actin.(2,3) Studies indicate that cadherin/catenin complexes are linked to the actin cytoskeleton via a direct association between alpha-actinin and alpha-catenin(4). The alpha-catenin protein has also been found to possess both actin binding and bundling activities (3). Adherens junctions (AJ) are required for both the establishment and maintenance of epithelial layers(5). These junctions have been identified in several other cell types, including cardiac myocytes and fibroblasts(5). AJ are multiprotein complexes that are assembled around cell adhesion molecules called cadherins. Cadherins are a multifunctional family of Ca2+-dependent transmembrane glycoproteins which promote cell-cell adhesion(6). The cadherin extracellular domain mediates homophilic interactions between like cadherin molecules on neighboring cells, while the intracellular domain interacts with several cytoplasmic proteins, such as alpha-catenin, beta-catenin, gamma-catenin (plakoglobin), and the tyrosine kinase substrate p120cas(1,7,8,9,10,11). Cadherin-catenin interactions are required for complete cadherin activity and regulate the interaction between cadherins and the actin-based cytoskeleton (1,4,6,8,10,11).
|
|
|
|
|
