| Synonyms | Tumor necrosis factor receptor 1, TNF-R1, TNF-RI, TNFR-I, p55, p60, Tnfrsf1a |
| Swiss Prot Num | P25118 |
| Immunogen | Extracellular domain of mouse TNFR1 expressed in E. coli. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Should it contain a precipitate we recommend microcentrifugation before use. Shelf life: one year from despatch. |
| References | 1. Sheenhan, K.C.F. et al. (1995) Monoclonal Antibodies Specific for Murine p55 and p75 Tumor Necrosis Factor Receptors: Identification of a Novel In Vivo Role for p75. J. Exp. Med.181: 607-617. |
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| Format | Reconstitution: Use 1 ml distilled water |
| ? | State: Lyophilised purified IgG fraction. |
| ? | Label: R. Phycoerythrin (RPE) |
| ? | Purification: Affinity Chromatography on Protein G. |
| ? | Buffer System: PBS buffer pH 7.4 with 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. |
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| Specificity | SM2245R recognises murine CD120a, which is the 55kD tumour necrosis factor receptor, also known as TNFRI and TNFRSF1A. Clone 55R-286 does not block the interaction of CD120a with TNF alpha and does not inhibit the functional activity of CD120a. |
| Application | Flow Cytometry: Use 10 ?l of neat-1/5 diluted antibody to label 10e6 cells in 100ul. |
| Background | CD120a is expressed by a wide variety of cells including myeloid cells, activated T cells and activated B cells. The ligands for CD120a are tumour necrosis factor alpha (TNF alpha) and lymphotoxin alpha (LTA). Receptor cross-linking by ligands TNF alpha and LTA induces a variety of cellular functions including NFkB activation, apoptosis and cell differentiation. |
| Concentration | 0.1 mg/ml |
