| Synonyms | Cortisol |
| Immunogen | Cortisol-3-(Ocarboxymethyl)oxime-BSA. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig Fraction. |
| ? | Purification: Affinity Chromatography on Protein G. |
| ? | Buffer System: PBS containing 0.09% Sodium Azide as preservative. |
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| Specificity | This antibody recognizes the glucocorticoid hormone cortisol, that is produced in the adrenal cortex and is involved in responses to stress. Cross Reactivities of this antibody: Cortisol: 100% Prednisolone: 38% 11-Deoxycortisol: 2.5% 17a-OHP: 0.4% Corticosterone: < 0.1% Cortisone: 23% |
| Application | RIA and ELISA. |
| Background | Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism. |
| Concentration | 5.0 mg/ml |
