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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
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DataSheet |
ÁÖ¹®/°ßÀû |
LCA-20-35898 |
MA1-950 |
Hamster Anti-Bcl-3 Monoclonal Antibody, Unconjugated, Clone Ham150-3.5/100 ug/Human, Mouse/Hamster |
1/EA |
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Subject
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Hamster Anti-Bcl-3 Monoclonal Antibody, Unconjugated, Clone Ham150-3.5 |
Description
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100 ug / Human, Mouse/Hamster |
Clonality
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Mono |
Company
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Thermo Scientific |
Application
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ELISA, Western Blot |
Conjugation
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Unconjugated |
Immunogen
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Bcl-3 |
Contents
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Immunogen: Full length mouse Bcl-3 protein. MA1-950 detects human and mouse Bcl-3 from transfected cells and shows no cross-reactivity to other Bcl isoforms. MA1-950 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~47 kDa protein representing Bcl-3 from C57BI/6 human T cells and Bcl-3 transgenic ms T cells. MA1-950 immunogen is full length Bcl-3 protein from mouse.B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. |
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