| Catalog Number | GTX15046 |
| Product Name | Bcl3 [Ham150-3.5] antibody |
| Product Description | Hamster monoclonal [Ham150 - 3.5] to Bcl3 |
| Synonyms | 602 | BCL3 | 109560 | P20749 | BCL4 | D19S37 | |
| Background | This gene is a protooncogene candidate. It is identified by its translocation into the immunoglobulin alpha locus in some cases of B cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co activator that activates through its association with NFkappa B homodimers. The expression of this gene can be induced by NFkappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NFkappa B. |
| Clonality | Monoclonal |
| Clone No | Ham150-3.5 |
| Host | Hamster |
| Isotype | IgG |
| Immunogen | Full length mouse Bcl3 protein. |
| Antigen Species | Mouse |
| Tested Applications | ELISA, Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | ELISA: Use at an assay dependent dilution. WB: Use at a concentration of 2 μg/ml. Detects a band of approximately 47 kDa (predicted molecular weight: 50 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Specificity | GTX15046 recognises Bcl3 from transfected cells and shows no cross reactivity to other Bcl isoforms. |
| Species Cross Reactivity | Cross-reacts with Human and Mouse. Not yet tested in other species. |
| Positive Controls | C57BI/6 human T cells and Bcl3 transgenic ms T cells |
| Target | Bcl3 |
| Cellular Localization | Nuclear |
| Form Supplied | Liquid |
| Purification | Protein G purified |
| Storage Buffer | Preservative: 0.05% Sodium Azide; Constituents: 1mg/ml BSA |
Image:img25213.jpgWestern blot of Bcl3 in transgenic mouse T cells using GTX15046 Print:Print
